Biological role of anti-aging protein klotho
WebKlotho is an aging suppressor protein that is abundant in kidney tissue and Klotho-knockout mice have been shown to develop a syndrome similar to premature aging (30,31). The present study focused on determining the relevance of radiation-induced cellular senescence and the involvement of Klotho.
Biological role of anti-aging protein klotho
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WebNovel Klotho-dependent mechanisms that are clinically relevant in aging and age-related diseases are discussed that include regulatory effects on general metabolism and a … Web2012). The systemic effects of Klotho protein appear to be primarily due to its circulating form of secreted soluble Klotho protein, which operates as a humoral factor (Chang et al. 2005) – potentially through bind-ing to its putative, yet still unknown, cell-surface receptor – and as an enzyme regulating the biological
WebKlotho plays a major role in kidney disease as much of the Klotho protein circulating in the blood is produced in the kidneys. ... Aging is a complex biological process regulated by multiple intrinsic and extrinsic factors such as genetics, epigenetics, environment, lifestyle, and immune response. Aging is often defined as an age-related ... WebDec 1, 2024 · For instance, Klotho is able to downregulate inflammatory cytokines and attenuate the generation of reactive oxygen species, acting as an anti-inflammatory protein (Kim et al., 2015). Although accelerated aging profile has been described in BD and the chronic low-grade inflammation is a feature of both BD and aging, the biology linking BD …
WebFormer member of the Abraham Lab at Boston University School of Medicine investigating the anti-aging protein, Klotho, and its role in … WebKlotho is an anti-aging factor mainly produced by renal tubular epithelial cells (TEC) with pleiotropic functions. Klotho is down-regulated in acute kidney injury in native kidney; …
WebFeb 19, 2024 · Klotho (KL), named after the Greek goddess of destiny who was the spinner of the thread of life, is involved in the aging process and may act as an anti-aging hormone in mammals. The KL gene is located in chromosome 13 in humans. It encodes a transmembrane protein with an extracellular domain, a transmembrane domain, and an …
WebMay 1, 2015 · Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. how to save lucky bamboo from dyingWebKlotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress. north face logo jacketsWebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney-specific ablation of Klotho which demonstrated the phenotype of global Klotho knockout mice. 21 The serum soluble Klotho was declined about 80% in those kidney-specific ... north face lone peak triclimateWebApr 10, 2024 · NANOG (Part 1): Its Role In Aging And Cancer. This is the first article in a series on the NANOG protein. Please see my companion series on klotho, another protein that may be involved in aging ... north face long black coatWebDec 1, 2024 · Klotho, an anti-aging protein (soluble or membrane-bound) plays a prominent role in understanding the aging process. It exerts various protective activities for neurons and multiple organs. Klotho ... how to save lumber tycoon 2WebNov 19, 2013 · The Klotho gene was identified as an ‘aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that include regulatory effects on general metabolism and a more specific effect … north face long coat for kidsWebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large role in the regulation of … how to save lower version of autocad