WebFeb 17, 2024 · A fully recombinant human monoclonal antibody therapy has begun phase 3 assessment for the treatment of idiopathic pulmonary fibrosis (IPF). Pamrevlumab, a connective tissue growth factor (CTGF) inhibitor, is now being dosed in patients with IPF participating in the ZEPHYRUS-2 phase 3 trial. WebMar 9, 2024 · p53 induces CTGF expression and promotes liver fibrosis; CTGF specifically induced the synthesis of decorin, suggesting a mechanism of autoregulation. This report provides novel evidence that CTGF confers cardioprotection by salvage phosphokinase signaling leading to inhibition of glycogen synthase kinase 3 beta, activation of phospho …
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WebSep 23, 2024 · CTGF, a downstream molecule of TGF-β/Smad, is a novel profibrotic factor that is up-regulated in the glomerulosclerosis of DN. Recent studies have identified that CTGF promotes the abnormal deposition of ECM and fibrosis and thus could enhance the disassembly and hypertrophy of mesangial cells . WebJul 14, 2024 · Peritoneal fibrosis (PF) is a serious complication in various clinical settings, but the mechanisms driving it remain to be fully determined. Connective tissue growth factor (CTGF) is known to ... ctrl facebook
Pamrevlumab, an anti-connective tissue growth factor …
WebUrinary CTGF excretion is reduced in patients with diabetic nephropathy treated with Losartan, an angiotensin converting enzyme inhibitor. In sum, these studies clearly show that there is a correlation between CTGF expression and fibrogenesis, but do not prove a cause-and-effect relationship between CTGF and fibrosis. WebHemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney Falke LL, Dendooven A, Leeuwis JW, … WebAug 6, 2024 · Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli and lead to kidney fibrosis. Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling … earth\\u0027s best non gmo plant based formula