Hif p53
Web1 de mai. de 2024 · Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-1α-binding site. The … Web17 de jul. de 2002 · The core domain of p53 (p53c) is the major folded unit of the protein. It harbors a sequence-specific DNA-binding site and frequently is mutated in human cancers ( 13 ). The level of p53 in the cell is tightly regulated in a similar fashion to that of HIF-1α. The protein Mdm2, an E3 ligase, is induced by p53 and acts as a feedback inhibitor ...
Hif p53
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Web31 de mar. de 2024 · Ad-SIRT3 treatment also regulated PHDs-HIF-1α levels in the hearts of diabetic db/db mice. Our study revealed a novel role of the HG-induced disruption of … Web摘要:目的 探讨乙酸钠(NaAc)对氧糖剥夺(OGD)损伤后皮质神经元的作用及低氧诱导因子-1α(HIF-1α)表达的影响。方法 将OGD处理的皮质神经元作为脑缺血模型,采用细胞存活实验(CCK-8)、乳酸脱氢酶(LDH)释放实验检测NaAc处理后的神经元存活情况,Western blot方法检测OGD损伤后、NaAc处理后神经元中HIF-1α蛋白 ...
Web18 de abr. de 2003 · Although hypoxia-inducible factor 1α (HIF-1α) has been implicated to be involved in p53 stabilization, the precise mechanism by which HIF-1α regulates p53-mediated function remains unknown. Here, we found that HIF-1α directly binds Mdm2 both in vitro and in vivo; in contrast, p53 fails to directly interact with HIF-1α in vitro. Web7 de jul. de 2024 · We found that HIF-1α and p53 are activated under different conditions. Under moderate hypoxia, HIF-1α is activated to induce glycolysis or angiogenesis, and …
Web1 de ago. de 2024 · HIF binds p53 in ovarian cancer cells. OVCA429, CAOV3, CAOV4, and TOV112D cells were incubated with or without TPT (25 nmol/L) for 48 hours under hypoxic conditions (0.5% O 2), and nuclear lysates were coimmunoprecipitated with anti–p53-conjugated agarose beads. Results shown are one representative experiment of three … Web31 de out. de 2024 · In particular, while HIF-1α recruits and shuttles mutant p53 to the DNA genomic elements, mutant p53 does not influence HIF-1 binding to the DNA but …
WebThe HIF-1a/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization. J Cell Mol Med 25:1700-1711 (2024). PubMed: 33438362; Charruyer A et al. Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis. Aging Cell …
WebRepositorio. Portal de Datos Abiertos UNAM, Colecciones Universitarias. 2,045,979. Repositorio de la Dirección General de Bibliotecas y Servicios Digitales de Información. 495,082. Biblioteca y Hemeroteca Nacional Digital de México. hosts ipv6 書き方Web26 de mai. de 2011 · Finally, the synergistic or antagonistic effects of p53 and HIF-1 on some important cellular pathways are discussed. Cell Death & Disease - Reciprocal … psychopathie und narzissmusWeb1 de set. de 1999 · The tumor-suppressor protein p53 is a known transcriptional activator within the central nervous system that is clearly involved in the pathologic response to … psychopathiform gedragWebImmunofluorescence staining of HIF-1 alpha in COS-7 cells with MA1-516 yields nuclear staining after exposing cells to 1% oxygen for 4 hours. In gel shift assays, MA1-516 has been successfully used only with mouse HIF-1 alpha. ... Hypoxia which induces p53 protein accumulation, ... psychopathie vererbbarWeb14 de ago. de 2013 · HIF-1 and/or p53 regulated genes mediating adaptation to cellular stresses through activation of different pathways. Upon hypoxia, the interaction between … psychopathietest von robert hareWebHIF-1 can initiate hypoxia mediated apoptosis by increasing the expression of Bcl-2 binding proteins—BNIP3 and NIX—thereby inhibiting the antiapoptotic effect of Bcl-2. A different mechanism of inducing apoptosis is by stabilisation of wild-type p53 by HIF-1. If the cell already has a p53 gene mutation, hypoxia induced apoptosis is prevented. hosts learning daycareWebLoss of p53 did not prevent the pharmacodynamic effects of PT2399, as measured by down-regulation of Cyclin D1 (SI Appendix, Fig. S2A). ... HIF-2 complex dissociation, target inhibition, and acquired resistance with PT2385, a first-in-class HIF-2 inhibitor, in patients with clear cell renal cell carcinoma. psychopathie und soziopathie