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WebRNF4 is a SUMO-targeted ubiquitin E3 ligase of Rta. connect ubiquitin- and SUMO-dependent DSB recognition, revealing that RNF4-synthesized hybrid SUMO-ubiquitin chains are … WebDescription: Homo sapiens BRCA1 DNA repair associated (BRCA1), transcript variant 2, mRNA. (from RefSeq NM_007300) RefSeq Summary (NM_007300): This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb … WebFeb 3, 2014 · Knockdown of the E3 ligase RNF4, which synthesizes hybrid SUMO-ubiquitin linkages, prevented efficient recruitment of RAP80 and BRCA1 to sites of DNA damage … black celine