Solubility of theophylline in water

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WebDec 7, 2024 · Theophylline salts — Several so-called "salts” of theophylline had been developed as attempts to increase water solubility (8 mg/mL at 25ºC) and improve absorption. While salts of theophylline may be formed with a base at high pH, theophylline is only slightly ionized at physiological pH (pK a = 8.8). WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was …

Extended Hildebrand solubility approach: solubility of theophylline …

WebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ... WebAug 3, 2010 · The solubility of theophylline in water was modeled including hydrate formation (1:1) as well as polymorphic transitions of theophylline between the anhydrate … simply be birmingham

Extended Hildebrand Solubility Approach: methylxanthines in …

WebJan 1, 2015 · Theophylline is dimethylxanthine which is closely related chemically to caffeine (Fig. 1 ). Like caffeine, theophylline is sparingly soluble in water (7 g/l). The logP value of theophylline is –0.02 giving the unionized form sufficient lipid solubility to diffuse passively through cell membranes. Theophylline is a weak acid (pKa 8.8). WebJan 1, 1975 · Melting Range The original synthetic literature27 reported a melting point 0 ; 264O for theophylline subsequently the melting range has been reported to be between 271° and 274O C.28 c Solubility The reported solubility of theophylline is 8.3 mg/ml in water; 12.5 mg/ml in ethanol; 11.f,Tg/ml in , Several chloroform; and sparingly soluble in ... WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. It was found that the solubility of theobromine, theophylline, … rayovac power bank review

RJPT - New Quantitative Technique for estimation of solubility of ...

Theophylline CAS#:58-55-9 Chemsrc

Web[Water soluble theophylline] [Water soluble theophylline] G Med Mil. Jul-Aug 1955;105(4):369-73. [Article in Italian] Author R RUGGIERI. PMID: 13277851 No abstract … WebJun 24, 2024 · This study aimed to assess the use of semi-solid extrusion-based 3D printing for the preparation of tailored doses of theophylline in the form of a chewable dosage form ... respectively. However, more importantly, GBP is freely soluble in water, whereas TPH is only slightly soluble in water [43,44], giving rise to a higher ... simply be black dressesWebAug 1, 2024 · The equilibrium solubility of caffeine and theophylline were determined in {methanol + water} binary mixtures at 298.15 K by means of the shaken flask method and … simply be black dresses plus size

"WebCaffeine, theobromine, and theophylline are all more fat soluble than they are water soluble. 5 mo. ago. Thank you! Does the extra methyl group on caffeine (as opposed to theophylline, theobromine and paraxanthine) not make a difference? Patrick26. The presence or absence of that methyl group does affect the solubilities, but they are still ... " - Solubility of theophylline in water

Solubility of theophylline in water

Theophylline - Coffee, Tea, Mate, Methylxanthines and …

WebJan 2, 2024 · Chemsrc provides Theophylline(CAS#:58-55-9) MSDS, density, melting point, boiling point, structure, formula, ... Solubility in water: slightly soluble Specific Gravity/Density: Molecular Formula: C7H8N4O2 Molecular Weight: 180.17 Section 10 - STABILITY AND REACTIVITY WebHowever, theophylline is only sparingly soluble in water and alcohol. The solubility of theophylline in water is 5.5 mg/mL, whereas in methanol and ethanol is 0.699 mg/mL and …

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WebThe solubility of the compound in water at 30 degrees (0.047 mg/ml) is 180-fold lower than that of theophylline (8.40 mg/ml). The complex is relatively stable in the alkaline pH range, but it hydrolyzes, releasing theophylline in acidic environments. The rate of theophylline release is pH dependent. WebMar 1, 1983 · The solubilities of theophylline and theophylline hydrate as a function of temperature are determined in the temperature range 288–365K. The solubility as a …

WebOct 9, 2013 · In this paper, the influence of polymorphs on the transformation water activity that corresponds to the transformation between hydrate and anhydrate of theophylline was investigated. Theophylline is known to exist either as anhydrates or a monohydrate. The transformation water activities of theophylline form II and IV were determined … WebIt is also moderately soluble in ethanol. Furthermore, it is soluble in alcohol (12.5 mg/ml), and chloroform (9.1 mg/ml), alkali hydroxides, ammonia, dilute hydrochloric or nitric acid, …

WebSolubility. Soluble in water (1.0 g/120 ml), ethanol (1.0 g/80 ml), chloroform (1.0 g/110 ml), hot water, ... and potassium salts and a large number of less basic salts and/or … WebTheophylline (3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione ); anhydrous, ≥ 99%, powder;

WebAug 1, 1994 · The results were treated on the basis of the extended Hildebrand solubility approach considering interaction terms. An equation has been obtained for predicting the …

WebThe solubility of theophylline in mixed solvents consisting of dioxane and water was determined at 25 +/- 0.1 degrees. The solubilities across this range of polar solvents were back-calculated using a technique involving an interaction energy term, W. rayovac power bankWebThe observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based on the Extended Simultaneous Chemical Reaction and … simply be black jumpsuitsWebAminophylline is soluble in water and insoluble in alcohol. Theophylline occurs as bitter-tasting, odorless, white, crystalline powder with a melting point between 270-274°C. It is sparingly soluble in alcohol and only slightly soluble in water at a pH of 7, but solubility increases with increasing pH. simply be black dressWebApr 14, 2024 · Purpose Nitrofurantoin is an effective antibacterial drug for the treatment of lower urinary tract infection. However, the anhydrate form can easily transform to the less soluble hydrate form (monohydrate) during dissolution, resulting in a reduction of dissolution rate and oral bioavailability. Therefore, inhibition of phase transformation is … rayovac portage wiWebJun 23, 2009 · The enthalpies of solution $$ \\Updelta_{sol}^{{}} H_{m}^{{}} $$ of polymorphic forms I and II of theophylline in water at 298.15 K using the isoperibol solution calorimeter have been determined in the range of concentration (0.311–1.547) · 10−3 /mol · kg−1. The enthalpies of hydration $$ \\Updelta_{hyd}^{{}} H_{m}^{o} $$ were determined … rayovac power guaranteeWebIn the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Compared to the solubility in distilled … simply be black jacketWebMar 4, 2010 · A homogeneous phase of IL and water was obtained by heating, while cooling of the homogeneous liquid mixture produced phase separation due to the decreased solubility. Briefly, 45 μL of [HMIM] [PF 6 ] was added to about 10 mL of a water sample, and this was then heated to 70 ºC, which enabled the IL to completely dissolve in water. simply be black sandals